Experimental and computational methods for identifying genetic variants impact on gene regulation

Roger Pique-Regi
Assistant Professor
Molecular Medicine and Genetics
Wayne State University School of Medicine
Presented in the Embryo Physics Course, January 22, 2014


In this talk I will present novel computational methods for identifying regulatory sequences and for modeling the molecular mechanisms of gene transcription control. The objective is to get better maps of tissue / cell-condition specific regulatory regions of the genome. The methods are also useful for characterizing variation across individuals and to obtain a better understanding of the impact of genetic variation on the molecular mechanisms of gene transcription regulation, and on complex traits. Our results indicate that disruption of protein binding to DNA as measured by DNaseI footprinting is a major mechanism underlying genetic variants that are associated with changes in gene expression. We expect that these genetic variants are likely to be important contributors to phenotypic variation.



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